Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice
نویسندگان
چکیده
منابع مشابه
Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice
We discovered that optical stimulation of the mystacial pad in Emx1-Cre;Ai27D transgenic mice induces whisker movements due to activation of ChR2 expressed in muscles controlling retraction and protraction. Using high-speed videography in anesthetized mice, we characterize the amplitude of whisker protractions evoked by varying the intensity, duration, and frequency of optogenetic stimulation. ...
متن کاملOptogenetic Stimulation of Cortex to Map Evoked Whisker Movements in Awake Head-Restrained Mice
Whisker movements are used by rodents to touch objects in order to extract spatial and textural tactile information about their immediate surroundings. To understand the mechanisms of such active sensorimotor processing it is important to investigate whisker motor control. The activity of neurons in the neocortex affects whisker movements, but many aspects of the organization of cortical whiske...
متن کاملVibrotactile Whisker Frequency Discrimination in Head-Fixed Mice
A Novel Two-alternative Forced Choice Paradigm for Bilateral 3 Vibrotactile Whisker Frequency Discrimination in Head-Fixed Mice 4 and Rats 5 Johannes M. Mayrhofer, Vida Skreb, Wolfger von der Behrens, Simon Musall, Bruno Weber and 6 Florent Haiss* 7 8 Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland 9 10 Running title: bilateral frequency discrimination in hea...
متن کاملOptogenetic regulation of leg movement in midstage chick embryos through peripheral nerve stimulation.
Numerous disorders that affect proper development, including the structure and function of the nervous system, are associated with altered embryonic movement. Ongoing challenges are to understand in detail how embryonic movement is generated and to understand better the connection between proper movement and normal nervous system function. Controlled manipulation of embryonic limb movement and ...
متن کاملNatural whisker-guided behavior by head-fixed mice in tactile virtual reality.
During many natural behaviors the relevant sensory stimuli and motor outputs are difficult to quantify. Furthermore, the high dimensionality of the space of possible stimuli and movements compounds the problem of experimental control. Head fixation facilitates stimulus control and movement tracking, and can be combined with techniques for recording and manipulating neural activity. However, hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.14140